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Article

Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α.

Thyroid : official journal of the American Thyroid Association - 1 Feb 2023

Kim Minjun, Kruhlak Michael, Hoffmann Victoria, Zerfas Patricia, Bishop Kevin, Doolittle Woo Kyung Lee, Edmondson Elijah F, Zhu Yuelin Jack, Cheng Sheue-Yann

Abstract excerpt

Background: Mutations of thyroid hormone receptor α (TRα1) result in resistance to thyroid hormone (RTHα), exhibiting symptoms of retarded growth, delayed bone maturation, anemia, and severe constipation. Using a mouse model of RTHα (Thra1PV/+ mouse), we aimed at understanding the molecular basis underlying the severe constipation observed in patients. Methods: The Thra1PV/+ mouse expresses a strong dominant...

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Identifiers

PMID: 36103385
DOI: 10.1089/thy.2022.0336
PMCID: PMC10081711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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