Article

GPR4 knockout attenuates intestinal inflammation and forestalls the development of colitis-associated colorectal cancer in murine models

2023-03-14

Abstract excerpt

GPR4 is a proton-sensing G protein-coupled receptor highly expressed in vascular endothelial cells and has been shown to potentiate intestinal inflammation in murine colitis models. Herein, we evaluated the proinflammatory role of GPR4 in the development of colitis-associated colorectal cancer (CAC) using the dextran sulfate sodium (DSS) and azoxymethane (AOM) mouse models in wild-type and GPR4 knockout mice. We f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af90fc51-89e1-5d99-b9ff-d5abb993ee29
DOI: 10.1101/2023.03.13.532341

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GPR4 knockout attenuates intestinal inflammation and forestalls the development of colitis-associated colorectal cancer in murine modelsDOI 10.1101/2023.03.13.532341Read

GPR4 Deficiency Alleviates Intestinal Inflammation in a Mouse Model of Inflammatory Bowel DiseaseSemantic proximity Read

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis modelSemantic proximity Read

GPR120 Prevents Colorectal Adenocarcinoma Progression by Sustaining The Mucosal Barrier IntegritySemantic proximity Read

GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociceptionSemantic proximity Read

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formationSemantic proximity Read

TDAG8 (GPR65) Inhibits Intestinal Inflammation in the DSS-Induced Experimental Colitis Mouse ModelSemantic proximity Read

Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1 <sup>+</sup> macrophages regulates the intestinal cytokine milieuSemantic proximity Read

Toll‐like receptor 4 regulates spontaneous intestinal tumorigenesis by up‐regulating IL‐6 and GM‐CSFSemantic proximity Read

Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer.Semantic proximity Read

Inflammatory bowel disease susceptible gene GPR35 promotes bowel inflammation in mice.Semantic proximity Read

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.Semantic proximity Read

Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice.Semantic proximity Read