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Article

Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis.

PloS one - 1 Jan 2013

Vanhooren Valerie, Vandenbroucke Roosmarijn E, Dewaele Sylviane, Van Hamme Evelien, Haigh Jody J, Hochepied Tino, Libert Claude

Abstract excerpt

Glycosylation is an essential post-translational modification, which determines the function of proteins and important processes such as inflammation. β-1,4-galactosyltransferase I (βGalT1) is a key enzyme involved in the addition of galactose moieties to glycoproteins. Intestinal mucins are glycoproteins that protect the gut barrier against invading pathogens and determine the composition of the intestinal...

Topics

Animals
Colitis
Dextran Sulfate
Disease Susceptibility
Female
Galactosyltransferases
Gene Expression
Humans
Inflammation
Intestinal Mucosa
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Microbiota

Phenotype

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 24339869
DOI: 10.1371/journal.pone.0079883
PMCID: PMC3855152

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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