Article

Fundamental transport mechanism of mucin-2 ER-to-Golgi trafficking identifies source of ER stress in inflammatory bowel disease

2024-05-15

Abstract excerpt

The intestinal mucous layer relies on mucin-2 secretion. While the mucin-2 secretory pathway has been studied, endoplasmic reticulum (ER) to Golgi apparatus (Golgi) trafficking remains poorly understood. The size of mucin-2 exceeds the capacity of regular coat protein complex II (COPII) vesicles, responsible for ER-to-Golgi transport. After confirming conventional secretion of mucin-2, we showed that COPII vesicle...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a14d7124-e775-502d-af9d-190a9db62cd6
DOI: 10.1101/2024.05.13.593851

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fundamental transport mechanism of mucin-2 ER-to-Golgi trafficking identifies source of ER stress in inflammatory bowel diseaseDOI 10.1101/2024.05.13.593851Read

N-glycosylation enzyme Mpi is essential for mucin O-glycosylation, host-microbe homeostasis, Paneth cell defense, and metabolismSemantic proximity Read

O-glycosylation regulates polarized secretion by modulating Tango1 stability.Semantic proximity Read

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.Semantic proximity Read

Mucins Dynamics in Physiological and Pathological ConditionsSemantic proximity Read

Mucin function in inflammatory bowel disease: an update.Semantic proximity Read

The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell developmentSemantic proximity Read

Autophagy prevents ER stress-induced Tight Junction barrier disruption via claudin-2 homeostasisSemantic proximity Read

The role of the Golgi apparatus in disease (Review).Semantic proximity Read

Golgi Complex: A Signaling Hub in CancerSemantic proximity Read

Gut microbiota shape the inflammatory response in mice with an epithelial defectSemantic proximity Read

Negative feedback by IRE1β optimizes mucin production in goblet cellsSemantic proximity Read

Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER.Semantic proximity Read