Article

The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucins

2021-11-30

Abstract excerpt

<h4>ABSTRACT</h4> Fucosylation of mucins, the main macrocomponents of the mucus layer that protects the digestive tract from pathogens, increases their viscoelasticity and shear stress resistance. These properties are altered in patients with ulcerative colitis (UC), which is marked by a chronic inflammation of the distal part of the colon. Here we show that the levels of Fucosyltransferase 8 (FUT8) and specific...

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Literature Corpus work: 6b4f87bc-6669-5970-b291-12870ef879fd
DOI: 10.1101/2021.11.30.469270

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