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Article

Accelerated Evolution in Distinctive Species Reveals Candidate Elements for Clinically Relevant Traits, Including Mutation and Cancer Resistance.

Cell reports - 6 Mar 2018

Ferris Elliott, Abegglen Lisa M, Schiffman Joshua D, Gregg Christopher

Abstract excerpt

The identity of most functional elements in the mammalian genome and the phenotypes they impact are unclear. Here, we perform a genome-wide comparative analysis of patterns of accelerated evolution in species with highly distinctive traits to discover candidate functional elements for clinically important phenotypes. We identify accelerated regions (ARs) in the elephant, hibernating bat, orca, dolphin, naked mole...

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Identifiers

PMID: 29514101
DOI: 10.1016/j.celrep.2018.02.008
PMCID: PMC6294302

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