Article
Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection.
PLoS genetics - 1 Jun 2012
Shibata Yoichiro, Sheffield Nathan C, Fedrigo Olivier, Babbitt Courtney C, Wortham Matthew, Tewari Alok K, London Darin, Song Lingyun, Lee Bum-Kyu, Iyer Vishwanath R, Parker Stephen C J, Margulies Elliott H, Wray Gregory A, Furey Terrence S, Crawford Gregory E
Abstract excerpt
Understanding the molecular basis for phenotypic differences between humans and other primates remains an outstanding challenge. Mutations in non-coding regulatory DNA that alter gene expression have been hypothesized as a key driver of these phenotypic differences. This has been supported by differential gene expression analyses in general, but not by the identification of specific regulatory elements...
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