Article
Analysis of human accelerated DNA regions using archaic hominin genomes.
PloS one - 1 Jan 2012
Burbano Hernán A, Green Richard E, Maricic Tomislav, Lalueza-Fox Carles, de la Rasilla Marco, Rosas Antonio, Kelso Janet, Pollard Katherine S, Lachmann Michael, Pääbo Svante
Abstract excerpt
Several previous comparisons of the human genome with other primate and vertebrate genomes identified genomic regions that are highly conserved in vertebrate evolution but fast-evolving on the human lineage. These human accelerated regions (HARs) may be regions of past adaptive evolution in humans. Alternatively, they may be the result of non-adaptive processes, such as biased gene conversion. We captured and...
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