Article

Integrated analysis sheds light on evolutionary trajectories of young transcription start sites in the human genome

2017-09-22

Abstract excerpt

Previous studies revealed widespread transcription initiation and fast turnover of transcription start sites (TSSs) in mammalian genomes. Yet how new TSSs originate and how they evolve over time remain poorly understood. To address these questions, we analyzed ∼200,000 human TSSs by integrating evolutionary and functional genomic data, particularly focusing on TSSs that emerged in the primate lineages. We found th...

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Literature Corpus work: 091fcd13-8cc1-5090-a216-e16e4ed98646
DOI: 10.1101/192757

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