Article

B lymphocytes in Treatment-Naïve Pediatric Lupus Patients are Epigenetically Distinct from Healthy Children

2022-09-25

Abstract excerpt

<h4>Background</h4> Systemic lupus erythematosus (SLE) is a complex disease likely triggered by gene-environment interactions. We have shown that most of the SLE-associated haplotypes encompass genomic regions enriched for epigenetic marks associated with enhancer function in neutrophils, and T and B cells, suggesting that genetic risk is exerted through altered gene regulation. Data remain scarce on how epigenet...

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Literature Corpus work: 0dade09f-93f4-5bfc-bbd5-cd6df78fffaa
DOI: 10.1101/2022.09.23.509218

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