Article
Genetics and epigenetics of systemic lupus erythematosus.
Current rheumatology reports - 1 Sept 2013
Costa-Reis Patrícia, Sullivan Kathleen E
Abstract excerpt
Genetics unquestionably contributes to systemic lupus erythematosus (SLE) predisposition, progression and outcome. Nevertheless, single-gene defects causing lupus-like phenotypes have been infrequently documented. The majority of the identified genetic SLE risk factors are, therefore, common variants, responsible for a small effect on the global risk. Recently, genome wide association studies led to the...
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