Article

Genome-wide discovery of SLE genetic risk variant allelic enhancer activity

2020-01-20

Abstract excerpt

Genome-wide association studies of Systemic Lupus Erythematosus (SLE) nominate 3,073 genetic variants at 91 risk loci. To systematically screen these variants for allelic transcriptional enhancer activity, we constructed a massively parallel reporter assay (MPRA) library comprising 12,396 DNA oligonucleotides containing the genomic context around every allele of each SLE variant. Transfection into the Epstein-Barr...

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Literature Corpus work: 0b851e8c-329a-5e39-b4b4-ca551edb20a0
DOI: 10.1101/2020.01.20.906701

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