Article

High-resolution Nanopore methylome-maps reveal random hyper-methylation at CpG-poor regions as driver of chemoresistance in leukemias

2022-10-09

Abstract excerpt

Aberrant DNA methylation at CpG dinucleotides is a hallmark of cancer and is associated with the emergence of resistance to anti cancer treatment, though molecular mechanisms and biological significance remain elusive. Genome scale methylation maps by currently used methods are based on chemical modification of DNA and are best suited for analyses of methylation at CpG rich regions (CpG islands). We report the fir...

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Literature Corpus work: 0d7478ef-2db7-53a9-b76b-564f2ec7c6ec
DOI: 10.1101/2022.10.09.511472

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High-resolution Nanopore methylome-maps reveal random hyper-methylation at CpG-poor regions as driver of chemoresistance in leukemiasDOI 10.1101/2022.10.09.511472Read

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