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Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia

29 Jul 2025

Abstract excerpt

Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe the Acute Leukemia Methylome Atlas, which includes robust models capable of accurately predicting AML subtypes. A genome-wide prognostic model as well as a targeted...

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PMID: 40730747
DOI: 10.1038/s41467-025-62005-4

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