Article

Multi-omics analysis of longitudinal patient samples reveals the molecular mechanism of AML progression

2024-06-02

Abstract excerpt

Relapse remains a determinant of treatment failure and contributes significantly to mortality in acute myeloid leukemia (AML) patients. Despite efforts to understand AML progression and relapse mechanisms, findings on acquired gene mutations in relapse vary, suggesting inherent genetic heterogeneity and emphasizing the role of epigenetic modifications. We conducted a multi-omics analysis using Omni-C, ATAC-seq, an...

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Literature Corpus work: 08327866-48ac-59b7-99df-a46148b29702
DOI: 10.1101/2024.05.28.593678

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