Article

Mitigating non-genetic resistance to checkpoint inhibition based on multiple states of immune exhaustion

2023-09-26

Abstract excerpt

<title>Abstract</title> <p>Despite the revolutionary impact of immune checkpoint inhibition on cancer therapy, the lack of response in a subset of patients, as well as the emergence of resistance, remain significant challenges. Here we explore the theoretical consequences of the existence of multiple states of immune cell exhaustion on response to checkpoint inhibition therapy. The emerging understanding is that...

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Literature Corpus work: 0d73ccbc-b4d5-520e-97e0-eebe3137ea64
DOI: 10.21203/rs.3.rs-3358908/v1

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