Article

Gaming the cancer-immunity cycle by synchronizing the dose schedules

2024-11-03

Abstract excerpt

We introduce a mathematical model of the cancer-immunity cycle and use it to test several hypotheses regarding the combination, timing, and optimization associated with chemotherapy and immunotherapy dosing schedules in the context of competition and selection pressure. A key conceptual idea is the value of synchronizing the dosing schedules with the fundamental period of the cancer-immunity cycle. The competitors...

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Identifiers and source

Literature Corpus work: 452e3a22-6914-5b07-8693-92419ed278b5
DOI: 10.1101/2024.10.31.621326

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