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Heterogeneity of Exhausted T Cell Subsets in Responders and Non-Responders Following Checkpoint Inhibition Therapy

2025-03-11

Abstract excerpt

<title>Abstract</title> <p>The emerging recognition of multiple states of T cell exhaustion, of which only some are targetable by checkpoint inhibitors, has provided new insights into the variability in patient responses to immunotherapy. We hypothesized that non-responders to therapy have a higher proportion of non-targetable, terminally exhausted T cells compared to responders. To investigate this, we analyzed...

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Literature Corpus work
479a6d33-f3e4-510d-b910-56fe7f13407b
DOI
10.21203/rs.3.rs-5663382/v1
Open publication

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Heterogeneity of Exhausted T Cell Subsets in Responders and Non-Responders Following Checkpoint Inhibition TherapyDOI 10.21203/rs.3.rs-5663382/v1
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