Article

Dynamic optimization of chemo–immunotherapy sequencing reveals phenotype-dependent regimens across tumor immune microenvironments

2025-11-29

Abstract excerpt

Cytotoxic chemotherapy and immune checkpoint inhibitors (ICIs) have transformed the management of advanced cancers, yet durable responses remain restricted to subsets of patients and strongly depend on the tumor immune microenvironment (TIME). Distinct “hot” and “cold” TIMEs differ in pre-existing effector T-cell activity and treatment-induced immunogenicity, suggesting that combination regimens should be tailored...

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Literature Corpus work: afd8bedb-359c-5e86-af4c-0986f904acb3
DOI: 10.1101/2025.11.26.690636

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