Article

Mathematical Model Predicts Tumor Control Patterns Induced by Fast and Slow CTL Killing Mechanisms

2023-07-20

Abstract excerpt

Immunotherapy has dramatically transformed the cancer treatment landscape largely due to the efficacy of immune checkpoint inhibitors (ICIs). Although ICIs have shown promising results for many patients, the low response rates in many cancers highlight the ongoing challenges in cancer treatment. Cytotoxic T lymphocytes (CTLs) execute their cell-killing function via two distinct mechanisms: a fast-acting, perforin-...

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Literature Corpus work: 75947f58-afb9-5889-8158-7b4a8ed7df2b
DOI: 10.1101/2023.07.19.548738

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