Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simulating CD8 T cell exhaustion: A comprehensive approach

12 Jun 2025

Abstract excerpt

exhausted states. Critically, this signature is observed in tumor infiltrating T cells from multiple human tumor types, validating the translational potential of this model for discovering therapies.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40678524
DOI: 10.1016/j.isci.2025.112897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simulating CD8 T cell exhaustion: A comprehensive approachPMID 40678524Read ↗

Simulating CD8 T Cell Exhaustion: A Comprehensive ApproachSemantic proximity Read ↗

CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?Semantic proximity Read ↗

Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacySemantic proximity Read ↗

Prioritizing exhausted T cell marker genes highlights immune subtypes in pan-cancerSemantic proximity Read ↗

T cell exhaustion in cancer: Mechanisms and clinical implicationsSemantic proximity Read ↗

Integrative AI-Enabled Virtual Cell Modeling Reveals a Clinically Relevant Latent Effector State of Human CD8⁺ T Cells Undetectable by Conventional AnalysesSemantic proximity Read ↗

Identification of Cellular Interactions in the Tumor Immune Microenvironment Underlying CD8 T Cell ExhaustionSemantic proximity Read ↗

Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learningSemantic proximity Read ↗

T Cell ExhaustionSemantic proximity Read ↗

CD8 T Cell Exhaustion During Chronic Viral Infection and CancerSemantic proximity Read ↗

Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion.Semantic proximity Read ↗

High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.