Article

Modeling CISH-KO TIL therapy: T-cell persistence and endogenous competition determine response in gastrointestinal cancer

2026-06-11

Abstract excerpt

<h4>Background</h4> Tumor-infiltrating lymphocyte (TIL) therapies have shown promise in murine models; however, early-phase clinical trials reveal substantial heterogeneity in treatment response across patients. Elucidating the biological drivers of this variability is critical for improving patient selection and therapeutic design. <h4>Methods</h4> We developed a mechanistic mathematical model of Cish -inactiv...

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Literature Corpus work: bc128b0f-895a-5583-8aa4-030e8c56b26d
DOI: 10.64898/2026.06.08.730755

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