Genetic and molecular signatures highlight diverse pathways linking obesity to type 2 diabetes.

doi:10.1038/s41467-026-74675-9

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Article

Genetic and molecular signatures highlight diverse pathways linking obesity to type 2 diabetes.

Nature communications - 8 Jul 2026

Mutie Pascal M, Stojanovic Tijana, Lo Faro Valeria, Karlsson Torgny, Johansson Åsa

Abstract excerpt

Obesity is a major risk factor for type 2 diabetes, a disease affecting approximately 10% of the global population. Obesity is a heterogeneous condition, with different components exerting distinct, and sometimes opposing, effects on type 2 diabetes risk. Here, we aim to identify molecular mechanisms through which distinct components of obesity influence risk for type 2 diabetes by integrating multi-omics data....

Topics

Diabetes Mellitus, Type 2
Humans
Obesity
Polymorphism, Single Nucleotide
Female
Body Mass Index
Genetic Predisposition to Disease
Male
Mendelian Randomization Analysis
Genome-Wide Association Study
Multiomics
Risk Factors

Source

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Identifiers

PMID: 42420302
DOI: 10.1038/s41467-026-74675-9
PMCID: PMC13347065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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