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Article

Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.

BMC medicine - 12 Jan 2022

Dashti Hassan S, Miranda Nicole, Cade Brian E, Huang Tianyi, Redline Susan, Karlson Elizabeth W, Saxena Richa

Abstract excerpt

BACKGROUND: Genetic and lifestyle factors have considerable effects on obesity and related diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank examined associations of a BMI polygenic risk score (PRS), and its interactions with lifestyle risk factors, with clinically measured BMI and clinical phenotypes. METHODS: The Mass General Brigham (MGB) Biobank is a hospital-based...

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Identifiers

PMID: 35016652
DOI: 10.1186/s12916-021-02198-9
PMCID: PMC8753909

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