Article
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities.
Nature medicine - 1 Nov 2025
Chami Nathalie, Wang Zhe, Svenstrup Victor, Obrero Virginia Diez, Hemerich Daiane, Huang Yi, Dashti Hesam, Manitta Eleonora, Preuss Michael H, North Kari E, Holm Louise Aas, Fonvig Cilius E, Holm Jens-Christian, Hansen Torben, Scheele Camilla, Rauch Alexander, Smit Roelof A J, Claussnitzer Melina, Loos Ruth J F
Abstract excerpt
Obesity is a heterogeneous condition not adequately captured by a single adiposity trait. We conducted a multi-trait genome-wide association analysis using individual-level data from 452,768 UK Biobank participants to study obesity in relation to cardiometabolic health. We defined continuous 'uncoupling phenotypes', ranging from high adiposity with healthy cardiometabolic profiles to low adiposity with unhealthy...
Topics
- Humans
- Obesity
- Adiposity
- Genome-Wide Association Study
- Male
- Female
- Middle Aged
- Polymorphism, Single Nucleotide
- Genetic Predisposition to Disease