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Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlas

2025-12-05

Abstract excerpt

Interferons (IFNs) orchestrate diverse immune responses, but distinguishing individual IFN contributions in human transcriptomic data is challenging due to overlapping interferon-stimulated gene (ISG) signatures and limited cell-type-specific datasets. To address this, we generated a single-cell transcriptomic atlas of IFN responses by stimulating primary human T, B, NK, and CD14 monocytes with IFN-I, IFN-II, and...

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Identifiers and source

Literature Corpus work
07e9b973-c946-5ed5-87d4-991b3bdcfbb3
DOI
10.64898/2025.12.02.691676
Open publication

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Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasDOI 10.64898/2025.12.02.691676
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