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Article

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition.

Rheumatology (Oxford, England) - 1 Aug 2023

Peeters Janneke G C, Boltjes Arjan, Scholman Rianne C, Vervoort Stephin J, Coffer Paul J, Mokry Michal, Vastert Sebastiaan J, van Wijk Femke, van Loosdregt Jorg

Abstract excerpt

OBJECTIVES: How the local inflammatory environment regulates epigenetic changes in the context of inflammatory arthritis remains unclear. Here we assessed the transcriptional and active enhancer profile of monocytes derived from the inflamed joints of JIA patients, a model well-suited for studying inflammatory arthritis. METHODS: RNA sequencing and H3K27me3 chromatin immunoprecipitation sequencing (ChIP-seq) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36625523
DOI: 10.1093/rheumatology/kead001
PMCID: PMC10396381

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