Article

Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAK inhibition

2021-11-20

Abstract excerpt

How the local inflammatory environment regulates epigenetic changes in the context of autoimmune diseases remains unclear. Here we assessed the transcriptional and active enhancer profile of monocytes derived from the inflamed joints of Juvenile Idiopathic Arthritis (JIA) patients, a model well-suited for studying autoimmune diseases. RNA-sequencing analysis demonstrated that synovial-derived monocytes display an...

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Literature Corpus work: dd4b186c-9c98-542b-af47-0114d97f93a3
DOI: 10.1101/2021.11.20.469222

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