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Article

Epigenetic signals that direct cell type–specific interferon beta response in mouse cells

2 Feb 2023

Abstract excerpt

The antiviral response induced by type I interferon (IFN) via the JAK-STAT signaling cascade activates hundreds of IFN-stimulated genes (ISGs) across human and mouse tissues but varies between cell types. However, the links between the underlying epigenetic features and the ISG profile are not well understood. We mapped ISGs, binding sites of the STAT1 and STAT2 transcription factors, chromatin accessibility, and...

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PMID: 36732019
DOI: 10.26508/lsa.202201823

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