Article
Abnormalities of the type I interferon signaling pathway in lupus autoimmunity.
Cytokine - 1 Oct 2021
Gallucci Stefania, Meka Sowmya, Gamero Ana M
Abstract excerpt
Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic condition linked to inflammation. Both IFNα and IFNβ trigger a signaling cascade that, through the activation of JAK1, TYK2, STAT1 and STAT2, initiates gene transcription of IFN stimulated genes (ISGs). Noteworthy, other STAT family members...
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