Article

Binding of CEP152 to PLK4 stimulates kinase activity to promote centriole assembly

2024-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Centriole duplication is regulated by polo-like kinase 4 (PLK4) and several conserved initiator proteins. The precise timing and regulation of PLK4 activation are critical for ensuring that centriole duplication occurs only once per cell cycle. While significant progress has been made in understanding how PLK4 is activated, many aspects remain unclear. Here, we show how CEP152 contributes to the...

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Literature Corpus work: e66d4faa-9a4d-58e0-a5a9-b3e0d4ee4427
DOI: 10.1101/2024.11.12.623205

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