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Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer

24 Feb 2022

Abstract excerpt

Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle. Aberration of the centrosome number is common in human tumors. At the core of centriole duplication is the conserved polo-like kinase 4, Plk4, and two structural proteins, STIL and Sas-6....

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PMID: 35269408
DOI: 10.3390/cells11050786

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Related research

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Research trail→

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Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on CancerPMID 35269408Read ↗

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Polo-like kinases and DNA damage checkpoint: beyond the traditional mitotic functionsSemantic proximity Read ↗

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The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.Semantic proximity Read ↗

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Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.Semantic proximity Read ↗

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