Article

Integrated analysis of ribosomal DNA copy number and methylation using nanopore long-read sequencing

2026-07-06

Abstract excerpt

Ribosomal RNA (rRNA) provides the structural and catalytic core of ribosomes and is encoded by ribosomal RNA genes (rDNA) arranged in tandem repeat arrays. rDNA copy number (CN) is highly dynamic, representing a clinically relevant form of structural variation, but its accurate quantification has been challenging due to its highly repetitive and GC-rich nature. Here, we present RICO (Ribosomal DNA Integrated Copy...

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Literature Corpus work: 1faa7491-3c43-5604-8d42-adf7c1d66429
DOI: 10.64898/2026.07.05.736662

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