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Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts

1 Sept 2000

Abstract excerpt

Ribosomal DNA (rDNA) metabolism has been implicated in cellular and organismal aging. The role of rDNA in premature and normal human aging was investigated by measuring rDNA gene copy number, the level of rDNA methylation, and rRNA expression during the in vitro senescence of primary fibroblasts from normal (young and old) donors and from Werner syndrome (WS) patients. In comparison to their normal counterparts,...

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Share to Chromosomal and Genetic Variations
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PMID: 10973920
DOI: 10.1096/fj.99-0926com

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