Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human rDNA and Cancer.

Cells - 8 Dec 2021

Smirnov Evgeny, Chmúrčiaková Nikola, Cmarko Dušan

Abstract excerpt

In human cells, each rDNA unit consists of the ~13 kb long ribosomal part and ~30 kb long intergenic spacer (IGS). The ribosomal part, transcribed by RNA polymerase I (pol I), includes genes coding for 18S, 5.8S, and 28S RNAs of the ribosomal particles, as well as their four transcribed spacers. Being highly repetitive, intensively transcribed, and abundantly methylated, rDNA is a very fragile site of the genome,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Intergenic
Share to DNA, Ribosomal
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Ribosomes

Share to RNA, Untranslated

Source

Open in PubMed Open full text

Identifiers

PMID: 34943960
DOI: 10.3390/cells10123452
PMCID: PMC8700125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human rDNA and Cancer.PMID 34943960Read ↗

Variability of Human rDNA.Semantic proximity Read ↗

The human ribosomal RNA gene is composed of highly homogenized tandem clustersSemantic proximity Read ↗

Ribosomal DNA copy number amplification and loss in human cancers is linked to tumor genetic context, nucleolus activity, and proliferation.Semantic proximity Read ↗

Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients.Semantic proximity Read ↗

IGS38, a lncRNA from the human rDNA intergenic spacer, regulates rRNA transcription by altering rDNA chromatin organisation and activating the transcription machinerySemantic proximity Read ↗

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of gliomaSemantic proximity Read ↗

The conservation landscape of the human ribosomal RNA gene repeatsSemantic proximity Read ↗

Ribosomal DNA methylation as stable biomarkers for detection of cancer in plasmaSemantic proximity Read ↗

Clarified an rDNA Gene Unit Pattern with (CTTT)n and (CT)n Microsatellites Aggregation Ahead of and Behind the Gene in Human GenomeSemantic proximity Read ↗

Downregulation of ribosomal RNA (rRNA) genes in human head and neck squamous cell carcinoma (HNSCC) cells is linked to rDNA promoter hypermethylationSemantic proximity Read ↗

Genetic context and proliferation determine contrasting patterns of copy number amplification and loss for 5S and 45S ribosomal DNA arrays in cancerSemantic proximity Read ↗

Ribosomal DNA arrays are the most H-DNA rich element in the human genomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.