Article

Defective folate metabolism causes germline epigenetic instability and distinguishes <i>Hira</i> as a phenotype inheritance biomarker

2020-05-25

Abstract excerpt

<h4>ABSTRACT</h4> The mechanism behind transgenerational epigenetic inheritance (TEI) is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr gt hypomorphic mutation results in TEI of congenital malformations. Either maternal grandparent can initiate this phenomenon, which persists for at least four wildtype generations. In...

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Literature Corpus work: 7aad3031-4c08-58a5-9390-4a63603f6697
DOI: 10.1101/2020.05.21.109256

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