Article
Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development.
Cell - 26 Sept 2013
Padmanabhan Nisha, Jia Dongxin, Geary-Joo Colleen, Wu Xuchu, Ferguson-Smith Anne C, Fung Ernest, Bieda Mark C, Snyder Floyd F, Gravel Roy A, Cross James C, Watson Erica D
Abstract excerpt
The importance of maternal folate consumption for normal development is well established, yet the molecular mechanism linking folate metabolism to development remains poorly understood. The enzyme methionine synthase reductase (Mtrr) is necessary for utilization of methyl groups from the folate cycle. We found that a hypomorphic mutation of the mouse Mtrr gene results in intrauterine growth restriction,...
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