Article

Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations

2024-02-23

Abstract excerpt

The etiology of neural tube defects (NTDs) involves complex gene-environmental interactions. Folic acid (FA) prevents NTDs, but the mechanisms remain poorly understood and at least 30% of human NTDs resist the beneficial effects of FA supplementation. Here, we identify the DNA demethylase TET1 as a nexus of folate-dependent one-carbon metabolism and genetic risk factors post-neural tube closure. We determine that...

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Literature Corpus work: 51267621-4bf2-51cd-87aa-fa73ba9566d0
DOI: 10.1101/2024.02.21.581196

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