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Article

Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.

Placenta - 1 Apr 2015

Himes K P, Young A, Koppes E, Stolz D, Barak Y, Sadovsky Y, Chaillet J R

Abstract excerpt

INTRODUCTION: Monoallelic expression of imprinted genes is necessary for placental development and normal fetal growth. Differentially methylated domains (DMDs) largely determine the parental-specific monoallelic expression of imprinted genes. Maternally derived DNA (cytosine-5-) -methyltransferase 1o (DNMT1o) maintains DMDs during the eight-cell stage of development. DNMT1o-deficient mouse placentas have a...

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Identifiers

PMID: 25662615
DOI: 10.1016/j.placenta.2015.01.012
PMCID: PMC4359963

Genes

DMD
MEST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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