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The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism

19 Aug 2013

Abstract excerpt

BACKGROUND Most reproductive failures originate during the periconceptional period and are influenced by the age and the lifestyle of parents-to-be. We advance the hypothesis that these failures can arise as a partial consequence of derangements to one-carbon (1-C) metabolism (i.e. metabolic pathways that utilize substrates/cofactors such as methionine, vitamin B12, folate). 1-C metabolic pathways drive the...

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PMID: 23959022
DOI: 10.1093/humupd/dmt041

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