Article

Defining the molecular interaction between influenza hemagglutinin and MHC-II

2026-07-22

Abstract excerpt

The hemagglutinin (HA) of some influenza viruses can interact with major histocompatibility complex class II (MHC-II), but how these proteins interact is unclear. Here we demonstrate that diverse H5 HAs can use MHC-II to enter cells, with avian MHC-II enabling more efficient entry than human MHC-II for most H5 HAs. To define the molecular interface, we use pseudovirus deep mutational scanning to measure how mutati...

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Identifiers and source

Literature Corpus work: 0c82bf27-d9b2-5bff-83e1-fa7d72adb322
DOI: 10.64898/2026.07.17.738765

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