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Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells

6 Jul 2023

Abstract excerpt

The viral hemagglutinins of conventional influenza A viruses (IAVs) bind to sialylated glycans on host cell surfaces for attachment and subsequent infection. In contrast, hemagglutinins of bat-derived IAVs target major histocompatibility complex class II (MHC-II) for cell entry. MHC-II proteins from various vertebrate species can facilitate infection with the bat IAV H18N11. Yet, it has been difficult to...

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PMID: 37410798
DOI: 10.1371/journal.pbio.3002182

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