Article
HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans.
EMBO reports - 1 Jan 2002
Victor Martin, Bei Yanxia, Gay Frederique, Calvo Dominica, Mello Craig, Shi Yang
Abstract excerpt
The p300/CBP family of transcriptional coactivators possesses multiple functional domains, including a histone acetyltransferase (HAT) and several activation domains. A number of models have been proposed to account for their roles in transcriptional activation, including interactions with basal transcription machinery and chromatin remodeling. However, individual contributions of these domains to transcriptional...
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