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Article

Emerging roles of p300/CBP in autophagy and autophagy-related human disorders

14 Jun 2023

Abstract excerpt

As one of the major acetyltransferases in mammalian cells, p300 (also known as EP300) and its highly related protein CBP (also known as CREBBP), collectively termed p300/CBP, is characterized as a key regulator in gene transcription by modulating the acetylation of histones. In recent decades, proteomic analyses have revealed that p300 is also involved in the regulation of various cellular processes by...

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PMID: 37314181
DOI: 10.1242/jcs.261028

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