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Article

Is histone acetylation the most important physiological function for CBP and p300?

Aging - 1 Apr 2012

Bedford David C, Brindle Paul K

Abstract excerpt

Protein lysine acetyltransferases (HATs or PATs) acetylate histones and other proteins, and are principally modeled as transcriptional coactivators. CREB binding protein (CBP, CREBBP) and its paralog p300 (EP300) constitute the KAT3 family of HATs in mammals, which has mostly unique sequence identity compared to other HAT families. Although studies in yeast show that many histone mutations cause modest or...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Acetyltransferases

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Share to Transcription, Genetic

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Source

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Identifiers

PMID: 22511639
DOI: 10.18632/aging.100453
PMCID: PMC3371760

Genes

CREBBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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