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Article

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.

Molecular and cellular biology - 1 Feb 2006

Kasper Lawryn H, Fukuyama Tomofusa, Biesen Michelle A, Boussouar Fayçal, Tong Caili, de Pauw Antoine, Murray Peter J, van Deursen Jan M A, Brindle Paul K

Abstract excerpt

The global transcriptional coactivators CREB-binding protein (CBP) and the closely related p300 interact with over 312 proteins, making them among the most heavily connected hubs in the known mammalian protein-protein interactome. It is largely uncertain, however, if these interactions are important in specific cell lineages of adult animals, as homozygous null mutations in either CBP or p300 result in early...

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Identifiers

PMID: 16428436
DOI: 10.1128/MCB.26.3.789-809.2006
PMCID: PMC1347027

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Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.PMID 16428436Read ↗

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