Article

Exploring human rare disease variants from a multidimensional perspective illuminates receptor – G protein coupling diversity

2024-01-17

Abstract excerpt

<h4>ABSTRACT</h4> G protein-coupled receptors (GPCRs) are transmembrane proteins capable of detecting signals as diverse as odours, neurotransmitters, and hormones. Upon activation, receptor signalling converges onto four Gα protein subtypes to regulate intracellular responses. Therefore, variation in a single Gα protein gene can potentially impact the function of numerous receptors. In this work, we have perform...

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Literature Corpus work: a979dae2-e382-5669-94e6-0f383fc66b3e
DOI: 10.1101/2024.01.16.575841

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