Article

APOBEC3 mediated mutagenesis and structural disruption of PIK3CA drive 5- FU resistance in colorectal cancer

2026-06-28

Abstract excerpt

<title>Abstract</title> <p>5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer (CRC), yet the development of drug resistance remains a major obstacle to long-term clinical success. The mechanisms underlying 5-FU resistance involve complex genetic and molecular alterations. In this study, we integrated population-based data, transcriptomic profiling, whole-exome sequencing, and stru...

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Literature Corpus work: 0c50defb-943c-5770-9780-494f2c84261e
DOI: 10.21203/rs.3.rs-8957808/v1

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