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Genetic Polymorphisms and Tumoral Mutational Profiles over Survival in Advanced Colorectal Cancer Patients: An Exploratory Study.

Current oncology (Toronto, Ont.) - 3 Jan 2024

Cayún Juan Pablo, Cerpa Leslie Carol, Colombo Alicia, Cáceres Dante Daniel, Leal José Luis, Reyes Felipe, Gutiérrez-Cáceres Carolina, Calfunao Susan, Varela Nelson Miguel, Quiñones Luis Abel

Abstract excerpt

Colorectal cancer is a common disease, both in Chile and worldwide. The most widely used chemotherapy schemes are based on 5-fluorouracil (5FU) as the foundational drug (FOLFOX, CapeOX). Genetic polymorphisms have emerged as potential predictive biomarkers of response to chemotherapy, but conclusive evidence is lacking. This study aimed to investigate the role of genetic variants associated with 5FU-based...

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PMID: 38248103
DOI: 10.3390/curroncol31010018
PMCID: PMC10814806

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