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Development of gemcitabine-modified miR-15a as a novel, multimodal treatment strategy to overcome 5-FU and oxaliplatin resistance in colorectal cancer

2026-04-29

Abstract excerpt

<h4>Background</h4> Resistance to 5-fluorouracil (5-FU)-based chemotherapy is a major clinical obstacle in colorectal cancer (CRC), highlighting the urgent need to overcome established resistance mechanisms. MicroRNA-based therapeutics have emerged as compelling candidates in this context, given their inherently pleiotropic mode of action; however, their clinical translation remains hindered by poor stability and...

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Literature Corpus work
10d56e09-a6ac-5526-acb2-d8deae791660
DOI
10.64898/2026.04.25.720825
Open publication

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